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Document Details :
Title: Een man met herhaald optredende trombo-embolische fenomenen
Author(s): DIERICKX D, PEERLINCK K, VERHAEGHE R
Journal: Tijdschrift voor Geneeskunde
Volume: 61 Issue: 10 Date: 2005
Recurrent idiopathic thromboembolism due to occult malignancy in a 42-year-old man
A 42-year-old man was admitted to the hospital because of recurrent idiopathic venous thromboembolism. The clinical presentation was highly suspect for an underlying occult malignancy. Extensive screening revealed the presence of a pulmonary adenocarcinoma.
The association between cancer and thrombosis has been described since 1865. The pathogenetic mechanism is complex and includes multifactorial processes. The majority of thrombotic events involves the venous system and can occur as a complication of all cancer types.
In most cases of venous thromboembolism there exists a known malignancy. However, it can occur as the first manifestation of an occult malignancy. In these cases the cancer is associated with an advanced stage and a poor prognosis. Extensive screening of patients with one episode of idiopathic thromboembolism does not seem to be recommended.