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Document Details :
Title: Neuropathische pijn: harde klinische eindpunten
Author(s): DEVULDER J
Journal: Tijdschrift voor Geneeskunde
Volume: 63 Issue: 8 Date: 2007
Neuropathic pain: hard clinical endpoints
Neuropathic pain has been defined as pain due to a primary nerve injury or caused by a dysfunction of the nervous system. This vague definition leads to great differences in the reported prevalences of neuropathic pain.
A large number of drugs has been proposed for the treatment of neuropathic pain; still in randomized controlled trials 1/3 of the patients do not perceive any pain relief at all, while the large majority of the remaining patients experience only a partial pain relief.
We suggest to move from the current disease-based classification of pain to a more mechanistic-based taxonomy classification with its specific therapy.
The current literature data only reveal that tricyclic antidepressants, anticonvulsants and opioids can exert some effect on neuropathic pain.