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Document Details :

Title: Lijnen van Beau
Author(s): FITZPATRICK C, LACOR P, MANA F
Journal: Tijdschrift voor Geneeskunde
Volume: 69    Issue: 7   Date: 2013   
Pages: 346-347
DOI: 10.2143/TVG.69.07.2001366

Abstract :
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Beau’s lines
Beau’s lines are deeply grooved horizontal lines on the fingernail due to a temporary cessation of cell division in the nail matrix. They lines can be caused by trauma or by diseases involving the entire body, including systemic diseases, malnutrition, myocardial infarction, severe infections, and metabolic disturbances. Beau’s lines may even result from any disease process severe enough to affect the growth plate of the nail.
The medical history of a 65-year-old female with a high fever, loss of apetite, weight loss, severe diarrhea and rectal bleeding since three weeks, is presented. She has been known with ulcerative colitis since 2006, while remaining free of symptoms for years.Further examination reveals a severe pancolitis.
Initial treatment with corticosteroids results in an only temporary improvement, thus a treatment with infliximab and azathioprine is started, leading to a favourable evolution of her symptoms. Later on, she also develops an infection with Clostridium difficile for which a treatment is initiated with good results.
During this hospitalisation distinct Beau lines are noticed on her fingernails. There are several possible causes for the lines, including the underlying ulcerative colitis, the treatment with azathioprine, or the Clostridium difficile infection.

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