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Document Details :
Title: Een patiënt met ernstige hypotensie tijdens algemene narcose
Author(s): EBO DG, STEVENS WJ
Journal: Tijdschrift voor Geneeskunde
Volume: 58 Issue: 16 Date: 2002
Flow cytometric analysis of in vitro activated basophils for the diagnosis of muscle relaxant allergy
Anaphylactic reactions during anaesthesia are mainly the result of muscle-relaxants, anaesthetics, analgesics and natural rubber latex. Skin tests, quantification of serum IgE against quaternary ammonium-bearing molecules, e.g. suxamethonium, and in vitro basophil histamine release are used to investigate muscle-relaxant allergy. However, the predictive value of these tests is relatively low.
Basophils activated with specific allergen which is recognised by surface receptor Fc
We describe a patient with esmeron allergy in which diagnosis could be established by the assay which we named the basophil activation test (BAT).