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Title: Gewijzigd elektrocardiogram bij een depressieve patiënte met cerebrovasculair accident
Author(s): PALMERS PJ, HOFKENS PJ, VANDERSTIGHELEN H, WILLEMS R
Journal: Tijdschrift voor Geneeskunde
Volume: 66    Issue: 11   Date: 2010   
Pages: 546-549
DOI: 10.2143/TVG.66.11.2000766

Abstract :
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ECG-changes in a depressed patient with stroke.
We report a case of a female patient who was admitted for urgent trombolysis because of stroke. She took lithiumcarbonate as chronic medication for a bipolar disorder. After two weeks of revalidation she developed a clinical picture of stupor, bradycardia, hypotension and vomiting. The ECG showed inversed T-waves in several leads and a lengthened QTc interval. The symptoms of this patient were caused by lithium intoxication.
Lithium is an efficient, cheap and frequently used drug in the treatment of bipolar disorders. It has a narrow therapeutic range and lithium intoxication can be life-threatening. Exacerbating factors, symptoms and treatment of lithium intoxication are discussed briefly.

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